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KMID : 0361420100340030253
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Journal of Korean Academy of Rehabilitation Medicine
2010 Volume.34 No. 3 p.253 ~ p.258
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Therapeutic Effect of the Recombinant Human Epidermal Growth Factor (rhEGF) in Pressure Ulcer
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Cho Kang-Hee
Kim Young-Jae
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Abstract
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Objective: To investigate the effect of the recombinant human epidermal growth factor (rhEGF) on pressure ulcer treatment.
Method: Eighteen patients who had stage 3 or 4 pressure ulcer were divided into two groups. For experimental group, we cleaned the wound with normal saline, applied 0.5 ml of EasyEF liquid? (rhEGF 0.5 mg/10 ml) and covered the wound with the humidified gauze 2 times a day. For control group, we cleaned with normal saline and covered with the medifoam for 2 times a day. We estimated the change of the size and the stage of the ulcer weekly for 4 weeks. The longest region of the wound was measured by the width, and the longest line perpendicular to the width was measured by the length.
Results: The width and length of the stage 3 ulcer of experimental group significantly decreased, while control group showed a slightly decreased. The experimental group showed significant improvement compared to the control group (p＜0.05) in stage 3 ulcer. In stage 4 ulcer treatment, there were no significant differences between the two groups. In experimental group, 5 regions of the six stage 3 ulcer improved into the stage 2 ulcer during the study, even though only 1 region improved into the stage 2 ulcer in control group.
Conclusion: We confirmed that rhEGF was effective in the stage 3 ulcer. rhEGF treatment may be useful for healing of the stage 3 ulcers. (J Korean Acad Rehab Med 2010; 34: 253-258)
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KEYWORD
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Recombinant human epidermal growth factor, Pressure ulcer
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